Database : HANSEN Search on : LINFOCITOS T SUPRESSORES-EFETORES/PA [Subject descriptor] References found : 13 [refine] Displaying: 1 .. 13   in format [Detailed]

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Id: 17514 Author: Kennedy, Cornelis; Lien, Roel A. M. Chin; Stolz, Ernst; Joost, Theodoor; Naafs, Bernard Title: Leprosy and human immunodeficiency virus infection: a closer look at the lesions ..- Source: s.l; s.n; 1990. 2 p. . Descriptors: Síndrome de Imunodeficiência Adquirida/*CO/PA Infecções por HIV/*CO/PA Ceratinócitos/PA Células de Langerhans/PA Hanseníase Dimorfa/CO/*PA Hanseníase Virchowiana/CO/*PA Linfócitos T Citotóxicos/PA Linfócitos T Auxiliadores-Indutores/PA Linfócitos T Supressores-Efetores/PA Limits: FEMININO ADULTO Humanos Location: BR191.1; 09234/s

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Id: 13577 Author: Mehra, Vijay; Convit, Jacinto; Rubinstein, Arye; Bloom, Barry R Title: Activated suppressor T cells in leprosy ..- Source: s.l; s.n; nov. 1982. 6 p. tab, graf. Abstract: Leprosy is a spectral disease in which the patients at the lepromatous end display selective immunologic unresponsiveness to antigens of M. leprae. We have previously explored the possibility that the anergy in lepromatous leprosy mediated by suppressor cells. An in vitro system was developed in which lepromin induces suppression of the mitogenic response of lepromatous and borderline but not tuberculoid leprosy patients to concavalin A.(AU). Descriptors: HANSENIASE/imunol HANSENIASE/terap LINFOCITOS T SUPRESSORES-EFETORES/imunol ANTIGENOS DE BACTERIAS/admin ANTIGENOS DE HISTOCOMPATIBILIDADE CLASSE II/imunol ANTIGENO DE MITSUDA/imunol RECEPTORES FC/genet IMUNOTERAPIA Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01419/s

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Id: 13500 Author: Mehra, Vijay; Mason, Llewellyn H; Fields, James P; Bloom, Barry R Title: Lepromin-induced suppressor cells in patients with leprosy ..- Source: s.l; s.n; oct. 1979. 5 p. tab, graf. Abstract: The possibility of an active mechanism of immunologic suppression in leprosy was explored by assessing the in vitro lymphocyte responses of 61 leprosy patients and 30 normal individuals to the mitogen Con A in the presence or absence of Dharmendra lepromin. Lepromin-induced suppression of Con A stimulation was found in 32 of 35 lepromatous patients and 15 of 15 borderline patients, but only 2 of 15 tuberculoid patients and 2 of 30 normal controls. Cell fractionation studies indicated at least two cell populations involved in the in vitro lepromin-induced suppressor activity, adherent cells and T gamma-cells.(AU). Descriptors: LINFOCITOS/clas TRANSFORMACAO LINFOCITICA HANSENIASE/imunol FORMACAO DE ROSETA LINFOCITOS T SUPRESSORES-EFETORES/imunol IMUNOGLOBULINA G/imunol ANTIGENO DE MITSUDA/imunol RECEPTORES FC/imunol CONCANAVALINA A/farmacol ADERÊNCIA CELULAR Limits: HUMANO SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01400/s

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Id: 13462 Author: Bach, Marie Anne; Chatenoud, Lucienne; Wallach, D; Phan Dinh Tuy, Françoise; Cottenot, F Title: Studies on T cell subsets and functions in leprosy ..- Source: s.l; s.n; jun. 1981. 10 p. tab, graf. Abstract: T cell subsets and T cell functions were explored in 31 leprosy patients with the following methods: determination of the percentages of the different T cell subpopulations defined by monoclonal antibodies directed at total T cells, helper T cells and suppressor/cytotoxic T cells; measurement of the in vitro proliferative responses to mitogens; study of the concanavalin A-induced suppressive activity, assessed on MLC; measurement of delayed-type hypersensitivity by skin testing. The confrontation between immunological lepromatous patients without type-2 reaction (erythema nodosum leprosum), (2) lepromatous patients without ENL (erythema nodosum leprosum), (2) lepromatous patients was recent ENL and (3) tuberculoid patients. Unexpectedly, groups 1 and 3, although differing strongly in their clinical status and their sensitivity to lepromin (absent in group 1 and strong in group 3), showed a similar immunological profile with a normal percentage of T cells and a normal distribution of T cells among the major T cell subset contrasting with a moderate decrease of proliferative responses to mitogens and impaired delayed-type hypersensitivity reactions. Concanavalin A-induced suppressive activity was type-2 reaction) strongly differed from both other groups, showing striking abnormalities other groups, showing striking abnormalities of the repartition of the T cell subsets, with increased percentages of helper T cells and decreased percentages of suppressor T cells, and elevated proliferative responses to mitogens. Concanavalin A-induced suppressive activity was reduced in most patients of this group. It is suggested that this imbalance between T cell subsets contributes to the occurrence of ENL reactions in lepromatous patients.(AU). Descriptors: ANTICORPOS MONOCLONAIS/imunol HANSENIASE/imunol TESTES INTRADERMICOS CONTAGEM DE LEUCOCITOS TRANSFORMACAO LINFOCITICA LINFOCITOS T/clas LINFOCITOS T/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol CONCANAVALINA A/farmacol Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01450/s

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Id: 13428 Author: Modlin, R. L; Gebhard, J. F; Taylor, C. R; Rea, T. H Title: In situ characterization of T lymphocyte subsets in the reactional states of leprosy ..- Source: s.l; s.n; jul. 1983. 8 p. ilus, tab. Abstract: Using monoclonal antibodies and the immunoperoxidase technique, the numbers and distribution of T lymphocyte subsets in the tissues of reactional states of leprosy (six reversal reaction, nine erythema nodosum leprosum (ENL) and two Lucio's reaction) were determined and compared with those found in stable, non-reactional patients (six tuberculoid, two borderline lepromatous and seven lepromatous). The pattern of segregation of the suppressor/cytotoxic phenotype at the periphery of the granuloma was found in both non-reactional tuberculoid lesions and reversal reactions, but was better developed in the former. In ENL and Lucio's reaction, as well as in non-reactional lepromatous tissue, the helper/inducer and suppressor/cytotoxic phenotypes were both admixed with the aggregated histiocytes. However, the helper/suppressor ratio in ENL (2.1 +/- 0.4) was significantly larger than that in non-reactional lepromatous tissue (0.7 +/- 0.4, P less than 0.001). The immature thymocyte antigen OKT6 was found on scattered large non-lymphoid cells, most commonly in tuberculoid and reversal reaction tissues, less commonly in ENL, but only irregularly in non-reactional lepromatous tissue. The peripheral pattern of the suppressor/cytotoxic phenotype may be an immunohistological reflection of a cell-mediated immune response common to both non-reactional tuberculoid and reversal reaction patients. The reversal of the helper/suppressor ratio in ENL as compared to non-reactional lepromatous disease suggests some role for cell-mediated immunity in the pathogenesis of ENL. The OKT6 positive cell is of unknown origin and function.(AU). Descriptors: PELE/patol CONTAGEM DE LEUCOCITOS HANSENIASE/imunol HANSENIASE/patol TECNICAS IMUNOENZIMATICAS LINFOCITOS T/imunol ERITEMA NODOSO/patol LINFOCITOS T AUXILIADORES-INDUTORES/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol ANTICORPOS MONOCLONAIS/imunol Limits: ESTUDO COMPARATIVO HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01386/s

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Id: 13329 Author: Salgame, Padmini R; Mahadevan, P. R; Antia, Noshir H Title: Mechanism of immunosuppression in leprosy: presence of suppressor factor(s) from macrophages of lepromatous patients ..- Source: s.l; s.n; jun. 1983. 8 p. tab, graf. Abstract: Human peripheral blood mononuclear cell proliferation induced by Mycobacterium leprae could...(AU). Descriptors: HANSENIASE/imunol LINFOCINAS/anal LINFOCINAS/farmacol FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/antag FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/anal FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/farmacol MYCOBACTERIUM LEPRAE/imunol LINFOCITOS T/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol - CONCANAVALINA A/farmacol  TOLERÂNCIA IMUNOLOGICA  TRANSFORMACAO LINFOCITICA  MACROFAGOS/imunol  MYCOBACTERIUM/imunol  FATORES SUPRESSORES IMUNOLOGICOS  FATORES DE TEMPO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01218/s

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Id: 13280 Author: Nath, Indira; Van Rood, J. J; Mehra, N. K; Vaidya, M. C Title: Natural supressor cells in human leprosy: the role of HDLA-D-identical peipheral lymphocytes and macrophages in the in vitro modulation of lymphoproliferative responses ..- Source: s.l; s.n; nov. 1980. 8 p. tab. Abstract: Six families with HLA-D-identical siblings suffering from leprosy were studied. Lymphocytes and macrophages isolated from the peripheral blood were co-cultured with allogeneic, HLA-D-identical cells and stimulated with M. Leprae antigens and concanavalin A. tuberculoid patients had circulating lymphocytes which showed marked functional suppression of lymphoproliferative responses to antigen and mitogen. In contrast, lepromatous patients showed weak lymphocyte suppressor activity. Macrophages derived from responder individuals augmented, while those derived from lepromatous patients inhibited, M. leprae-induced proliferation of lymphocytes.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol CONCANAVALINA A/farmacol ANTIGENOS DE HISTOCOMPATIBILIDADE CLASSE II IMUNIDADE CELULAR HANSENIASE/genet HANSENIASE/imunol TRANSFORMACAO LINFOCITICA MACROFAGOS/imunol MYCOBACTERIUM LEPRAE/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 00544/s

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Id: 13268 Author: Bach, Marie-Anne; Chatenoud, Lucienne; Wallach, D; Phan Dinh Tuy, F; Cottenot, F Title: Studies on T cell subsets and functions in leprosy ..- Source: s.l; s.n; jun. 1981. 10 p. tab, graf. Abstract: T cell subsets and T cell functions were explored in 31 leprosy patients with the following methods: determination of the percentages of the different T cell subpopulations defined by monoclonal antibodies directed at total T cells, helper T cells and suppressor/cytotoxic T cells; measurement of the in vitro proliferative responses to mitogens; study of the concanavalin A-induced suppressive activity, assessed on MLC; measurement of delayed-type hypersensitivity by skin testing. The confrontation between immunological lepromatous patients without type-2 reaction (erythema nodosum leprosum), (2) lepromatous patients without ENL (erythema nodosum leprosum), (2) lepromatous patients was recent ENL and (3) tuberculoid patients. Unexpectedly, groups 1 and 3, although differing strongly in their clinical status and their sensitivity to lepromin (absent in group 1 and strong in group 3), showed a similar immunological profile with a normal percentage of T cells and a normal distribution of T cells among the major T cell subset contrasting with a moderate decrease of proliferative responses to mitogens and impaired delayed-type hypersensitivity reactions. Concanavalin A-induced suppressive activity was type-2 reaction) strongly differed from both other groups, showing striking abnormalities other groups, showing striking abnormalities of the repartition of the T cell subsets, with increased percentages of helper T cells and decreased percentages of suppressor T cells, and elevated proliferative responses to mitogens. Concanavalin A-induced suppressive activity was reduced in most patients of this group. It is suggested that this imbalance between T cell subsets contributes to the occurrence of ENL reactions in lepromatous patients.(AU). Descriptors: ANTICORPOS MONOCLONAIS/imunol CONCANAVALINA A/farmacol TESTES INTRADERMICOS HANSENIASE/imunol CONTAGEM DE LEUCOCITOS TRANSFORMACAO LINFOCITICA LINFOCITOS T/clas LINFOCITOS T/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01569/s

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Id: 11031 Author: Sieling, Peter A; Modlin, Robert L Title: Regulation of cytokine patterns in leprosy ..- Source: s.l; s.n; 1994. 11 p. . Descriptors: RELAÇAO CD4-CD8 CITOCINAS EXPRESSAO GENICA INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-7 INTERLEUCINAS HANSENIASE RNA MENSAGEIRO RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA RECEPTORES PARA ANTIGENOS DE CÉLULAS T GAMA-DELTA SUB-POPULAÇOES DE LINFOCITOS T LINFOCITOS T AUXILIADORES-INDUTORES LINFOCITOS T SUPRESSORES-EFETORES Location: BR191.1; 07209/s

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Id: 10297 Author: Naumov, V. Z; Saroiants, L. V; Balybin, E. S Title: Effects of endogenous cortisol on the function of nonspecific T-suppressors and quantitative characteristics of main subpopulations of circulating T-lymphocytes in leprosy ..- Source: s.l; s.n; 1995. 3 p. . Descriptors: HIDROCORTISONA HIDROCORTISONA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA SUB-POPULAÇOES DE LINFOCITOS T LINFOCITOS T SUPRESSORES-EFETORES POLINEUROPATIAS/ET Limits: ESTUDO COMPARATIVO Location: BR191.1; 07399/s

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Id: 9745 Author: Mutis, Tuna; Cornelisse, Yolanthe E; Datema, Gert; Van Den Elsen, Peter J; Ottenhoff, tom H. M; Vries, Rene R. P. de Title: Definition of a human suppressor T-cell epitope ..- Source: s.l; s.n; 1994. 5 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS LINFOCITOS T CD4-POSITIVOS CÉLULAS CLONAIS EPITOPOS EPITOPOS ANTIGENO HLA-DR2 HANSENIASE TRANSFORMAÇAO LINFOCITICA COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE REAÇAO EM CADEIA POR POLIMERASE RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA RECEPTORES PARA ANTIGENOS DE CÉLULAS T ALFA-BETA PROTEINAS RECOMBINANTES PELE LINFOCITOS T SUPRESSORES-EFETORES Location: BR191.1; 06704/s

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Id: 9704 Author: Bloom, Barry R; Modlin, Robert L; Salgame, Padmini Title: Stigma variations: observations on supppressor T cells and leprosy ..- Source: s.l; s.n; 1992. 36 p. graf. Descriptors: HANSENIASE LINFOCITOS LINFOCITOS T SUPRESSORES-EFETORES LINFOCINAS Location: BR191.1; 06646/s

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Id: 7643 Author: Modlin, Robert L; Rea, Thomas H Title: Leprosy: new insight into an ancient disease ..- Source: s.l; s.n; 1987. 13 p. ilus, graf. Abstract: Patients with leprosy may be classified into two clinical and histopathologic categories. At one end of the spectrum, patients with tuberculoid leprosy have few skin lesions in which organisms can rarely be identified. At the other end of the spectrum, patients with lepromatous leprosy have numerous skin lesions containing myriad bacilli. Because immunologic resistance is associated with this spectrum, the study of leprosy provides a unique opportunity to gain insight into immunoregulatory mechanisms in man. In addition, serodiagnosis to identify early cases and prevention by vaccination are areas of active research. For patient care, a network of Regional Hansen's Disease Centers has been established under the sponsorship of the National Program for Hansen's Disease, Carville, LA. Because the patients are often poor, their receipt of care and medication without cost helps to ameliorate at least one of the burdens imposed by this potentially devastating illness. The program central office may be called at 800-642-2477. (AU). Descriptors: INTERFERON TIPO II/IM INTERLEUCINA-2/IM HANSENIASE/*/DI/IM/PA/TH MACROFAGOS/IM/PA TESTES SOROLOGICOS LINFOCITOS T AUXILIADORES-INDUTORES/IM/PA LINFOCITOS T SUPRESSORES-EFETORES/IM/PA Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Location: BR191.1; 0120/cme

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